Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Spatial architecture contributes to failure of bulk biomarker-guided neoadjuvant immunotherapy selection in bladder cancer: The DUTRENEO study.

Cell reports. Medicine·2026

Same author

Frailty identifies early and non-cardiac healthcare utilization after cardiovascular hospitalization.

Frontiers in cardiovascular medicine·2026

Same author

Circulating Adipsin as a Biomarker of Liver Fat Content in Prepubertal Children Born Small-for-Gestational-Age.

International journal of molecular sciences·2026

Same author

Factors associated with frailty in older adults hospitalized for cardiovascular disease: A multidimensional cross-sectional observational study.

Geriatric nursing (New York, N.Y.)·2026

Same author

Nurse-Led Health Education Intervention on Basic Life Support for Relatives of Patients With Cardiac Conditions: A Quasi-Experimental Pilot Study.

Nursing & health sciences·2026

Same author

Enfortumab vedotin in ECOG-PS 2 advanced urothelial carcinoma patients: a real-world study from the ARON-2<sup>EV</sup> project.

BMC cancer·2026

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

Primary cardiac osteosarcoma.

María López¹, Alvaro Pinto, Víctor Moreno

¹Internal Medicine Department, Hospital La Paz, Madrid, Spain. alvaro_pinto_marin@hotmail.com

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

|August 1, 2008

Summary

Primary cardiac osteosarcoma is a rare malignant heart tumor. This case report details a 70-year-old woman with left atrial osteosarcoma, highlighting disease relapse and metastasis despite surgical removal.

More Related Videos

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Related Experiment Videos

Last Updated: Jul 3, 2026

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Area of Science:

Cardiology
Oncology
Pathology

Background:

Primary cardiac neoplasms are rare, with sarcomas constituting over 95% of malignant cases.
Most heart tumors are metastatic rather than primary.
Osteosarcoma is an uncommon primary malignant tumor of the heart.

Observation:

A case of a 70-year-old woman with primary cardiac osteosarcoma originating in the left atrium is presented.
The patient underwent complete tumor excision.
Despite successful surgery, the patient experienced disease relapse and developed metastatic disease.

Findings:

Primary cardiac osteosarcoma, though rare, can exhibit aggressive behavior with a propensity for recurrence and metastasis.
Complete surgical excision may not prevent disease progression in all cases of cardiac osteosarcoma.
The management and therapeutic options for this rare entity require careful consideration.

Implications:

This case underscores the importance of vigilant follow-up for patients with primary cardiac osteosarcoma.
Further research into optimal therapeutic strategies for cardiac osteosarcoma is warranted.
Understanding the behavior of rare cardiac tumors like osteosarcoma can inform clinical decision-making and improve patient outcomes.