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Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Biomaterials in orthopaedics
M Navarro1, A Michiardi, O Castaño
1Biomaterials, Implants and Tissue Engineering, Institute for Bioengineering of Catalonia (IBEC), CIBER-BBN, 08028 Barcelona, Spain. mnavarro@ibec.pcb.ub.es
Journal of the Royal Society, Interface
|August 1, 2008
Summary
Orthopaedic biomaterials have evolved over 50 years through three generations, from bioinert to bioactive and now molecularly targeted materials, addressing unmet needs in bone and joint repair.
Area of Science:
- Biomaterials Science
- Orthopaedics
- Regenerative Medicine
Background:
- Significant unmet needs persist in orthopaedics for bone and joint substitution and defect repair.
- The field of biomaterials has seen substantial advancements over the past 50 years.
Purpose of the Study:
- To review the evolution of biomaterials used in orthopaedic applications.
- To discuss different materials and approaches for addressing orthopaedic challenges.
Main Methods:
- Review of literature on biomaterials in orthopaedics.
- Analysis of the progression through three generations of biomaterials: bioinert, bioactive/biodegradable, and molecularly targeted.
Main Results:
- Biomaterials have progressed from bioinert (1st gen) to bioactive and biodegradable (2nd gen).
- Current third-generation biomaterials are designed for specific molecular-level interactions.
- Metals, ceramics, and polymers are key materials discussed in their orthopaedic evolution.
Conclusions:
- The evolution of biomaterials offers promising solutions for current orthopaedic demands.
- Continued innovation in biomaterials is crucial for advancing bone and joint repair and regeneration.
