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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
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Viral Hepatitis I: Introduction

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Cytomegalovirus Disease

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Conjugated Proteins

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Related Experiment Video

Updated: Jul 3, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

Apolipoprotein c1 association with hepatitis C virus.

Jean-Christophe Meunier1, Rodney S Russell, Ronald E Engle

  • 1Viral Envelopes and Retrovirus Engineering, Human Virology Department, INSERM U758, Ecole Normale Supérieure de Lyon, 46 allée d'Italie, 69364 Lyon Cedex 07, France. jean-christophe.meunier@ens-lyon.fr

Journal of Virology
|August 1, 2008
PubMed
Summary

Apolipoprotein C1 (ApoC1) is a key component of Hepatitis C virus (HCV) particles, crucial for viral replication. Targeting ApoC1 effectively neutralizes HCV infectivity, offering a potential therapeutic strategy.

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Area of Science:

  • Virology
  • Hepatology
  • Immunology

Background:

  • Cellular lipoprotein components are implicated in Hepatitis C virus (HCV) assembly.
  • The specific role of apolipoprotein C1 (ApoC1) in HCV morphogenesis and infection remains largely undefined.

Purpose of the Study:

  • To elucidate the involvement of apolipoprotein C1 (ApoC1) in Hepatitis C virus (HCV) infection.
  • To investigate the association of ApoC1 with infectious HCV particles and its impact on viral infectivity.

Main Methods:

  • Utilized Hepatitis C virus pseudotyped particle (HCVpp) and cell culture (HCVcc) systems.
  • Analyzed authentic HCV from infected chimpanzees.
  • Employed immunoprecipitation with anti-ApoC1 antibodies and infectivity neutralization assays using anti-ApoC1 antibodies and peptides.

Main Results:

  • ApoC1 was identified as a component of HCVcc and authentic HCV virions.
  • Anti-ApoC1 antibodies neutralized the infectivity of both HCVpp and HCVcc.
  • Peptides from ApoC1's C-terminal region inhibited HCV infectivity, suggesting intracellular association during viral assembly.

Conclusions:

  • Apolipoprotein C1 (ApoC1) is integral to Hepatitis C virus (HCV) virions.
  • ApoC1 plays a significant role in the HCV replication cycle, potentially mediating viral assembly and infectivity.