Related Experiment Video

Updated: Jul 3, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

Matched case-control study of effectiveness of live, attenuated S79 mumps virus vaccine against clinical mumps

Chuanxi Fu1, Jianhua Liang, Ming Wang

  • 1Department of Expanded Programmed Immunization, Guangzhou Center for Disease Control and Prevention, Guangzhou, China. fuchuanxi@gmail.com

Clinical and Vaccine Immunology : CVI
|August 1, 2008
PubMed

Insights

The S(79) mumps vaccine effectively prevents clinical mumps in children. A second dose is recommended for sustained protection, especially in the long term.

Area of Science:

  • Virology
  • Immunology
  • Pediatrics

Background:

  • Mumps virus infection poses risks to children and young adults.
  • The S(79) live, attenuated mumps virus vaccine has been available in China since 1990 without prior efficacy assessment.
  • Clinical mumps remains a concern in pediatric populations.

Purpose of the Study:

  • To evaluate the effectiveness of the S(79) mumps virus vaccine against clinical mumps.
  • To determine the impact of one versus two doses on vaccine effectiveness.
  • To assess vaccine effectiveness over time post-vaccination.

Main Methods:

  • A case-control study design was employed.
  • Cases and controls (n=469 each) were matched by gender, age, and residency.
  • Vaccination data were retrieved from the Children's Expanded Program on Immunization Administrative Computerized System.

Main Results:

  • One dose of the S(79) vaccine demonstrated 86.0% effectiveness (95% CI, 77.2% to 91.5%) against clinical mumps.
  • Vaccine effectiveness waned significantly between 5 to 12 years post-vaccination compared to the first 4 years.
  • A higher effectiveness was observed with two doses, indicating the need for a booster.

Conclusions:

  • The S(79) mumps virus vaccine is effective in preventing clinical mumps.
  • A second dose of the mumps vaccine is crucial for ensuring long-term protection in children in China.
  • Public health strategies should consider a two-dose schedule for optimal mumps prevention.

More Related Videos

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Micro-Colony Forming Unit Assay for Efficacy Evaluation of Vaccines Against Tuberculosis06:26

Micro-Colony Forming Unit Assay for Efficacy Evaluation of Vaccines Against Tuberculosis

Published on: July 28, 2023

Related Concept Videos

Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Vaccinations01:51

Vaccinations

Overview
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...