Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

ATP Driven Pumps III: V-type Pumps

ATP Driven Pumps III: V-type Pumps

V-type pumps are ATP-driven pumps found in the vacuolar membranes of plants, yeast, endosomal and lysosomal membranes of animal cells, plasma membranes of a few specialized eukaryotic cells, and some prokaryotes. They are also known as the V1Vo-ATPase, that couple ATP hydrolysis to transport protons against a concentration gradient.
The peripheral or cytosolic V1 domain with eight subunits is involved in ATP hydrolysis. The integral or transmembrane V0 domain containing at least five subunits...

Hormonal Regulation of Blood Pressure

Hormonal Regulation of Blood Pressure

Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction while...

Overview of Secretory Vesicles

Overview of Secretory Vesicles

Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...

Endocrine Signaling

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...

Hormonal Regulation

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Volume-based bias in automated measurements of lateral ventricle and hippocampal volumes of mild traumatic brain injury patients.

Neuroimage. Reports·2026

Same author

Tracing the impact of electrophysiological studies of magnocellular neurons.

Progress in neurobiology·2026

Same author

Analyzing Notebook Histories to Understand Data Visualization Workflows.

IEEE transactions on visualization and computer graphics·2026

Same author

Electrophysiological recording of hypothalamic brain regions in vivo using the transpharyngeal surgical approach in the rat.

Journal of neuroendocrinology·2026

Same author

How Micronutrient Status May Affect Eating Behavior-Hypothesis and Perspectives.

Nutrients·2026

Same author

Hydrothermal Synthesis and Electronic and Optical Characterization of Ag<sub>2</sub>(NH<sub>4</sub>)AsS<sub>4</sub>.

Inorganic chemistry·2026

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

Culturing Primary Rat Inner Medullary Collecting Duct Cells

Culturing Primary Rat Inner Medullary Collecting Duct Cells

Published on: June 21, 2013

Population dynamics in vasopressin cells.

Gareth Leng¹, Colin Brown, Nancy Sabatier

¹Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK. gareth.leng@ed.ac.uk

Neuroendocrinology

|August 1, 2008

Summary

This summary is machine-generated.

Neurons must maintain a constant response to unchanging stimuli to encode absolute levels. The vasopressin system sustains hormone secretion proportional to plasma osmolality, enabling water balance regulation.

More Related Videos

In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ

In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ

Published on: September 10, 2016

Kinetic Analysis of Vasculogenesis Quantifies Dynamics of Vasculogenesis and Angiogenesis In Vitro

Kinetic Analysis of Vasculogenesis Quantifies Dynamics of Vasculogenesis and Angiogenesis In Vitro

Published on: January 31, 2018

Related Experiment Videos

Last Updated: Jul 3, 2026

Culturing Primary Rat Inner Medullary Collecting Duct Cells

Culturing Primary Rat Inner Medullary Collecting Duct Cells

Published on: June 21, 2013

In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ

In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ

Published on: September 10, 2016

Kinetic Analysis of Vasculogenesis Quantifies Dynamics of Vasculogenesis and Angiogenesis In Vitro

Kinetic Analysis of Vasculogenesis Quantifies Dynamics of Vasculogenesis and Angiogenesis In Vitro

Published on: January 31, 2018

Area of Science:

Neuroscience
Endocrinology
Physiology

Background:

Neurons typically adapt to constant stimuli, prioritizing change detection.
Encoding absolute stimulus levels requires sustained neuronal responses.
The vasopressin system regulates water balance by sensing plasma osmolality.

Purpose of the Study:

To investigate the mechanisms enabling vasopressin cells to sustain responses to constant stimuli.
To explore how vasopressin cells coordinate to manage secretory load.
To understand the encoding of absolute plasma osmolality by vasopressin neurons.

Main Methods:

Exploration of cellular mechanisms in vasopressin cells.
Analysis of vasopressin secretion dynamics.
Investigation of inter-neuronal coordination in the vasopressin system.

Main Results:

Vasopressin cells can sustain responses to constant plasma osmolality.
Mechanisms exist for both sustained secretion and dynamic response adjustment.
Cellular coordination helps distribute the secretory demands across the vasopressin system.

Conclusions:

Vasopressin cells possess unique properties to encode absolute plasma osmolality.
Sustained signaling and adaptive responses are crucial for osmoregulation.
Inter-neuronal coordination optimizes the function of the vasopressin neurosecretory system.