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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
Epigenetic Regulation01:37

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Constitutive and Regulated Gene Expression01:27

Constitutive and Regulated Gene Expression

Gene expression in prokaryotes is governed by constitutive and regulated systems, allowing cells to balance the production of essential proteins with adaptive responses to environmental changes.Constitutive Gene ExpressionConstitutive, or housekeeping, genes are continuously expressed as they encode proteins vital for fundamental cellular processes. These include enzymes for glycolysis, ribosomal components for protein synthesis, and proteins involved in DNA replication. Their constant...
Operon Model01:23

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Related Experiment Video

Updated: May 13, 2026

The Use of Chemostats in Microbial Systems Biology
13:19

The Use of Chemostats in Microbial Systems Biology

Published on: October 15, 2013

Metabolic gene regulation in a dynamically changing environment.

Matthew R Bennett1, Wyming Lee Pang, Natalie A Ostroff

  • 1Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, USA.

Nature
|August 1, 2008
PubMed
Summary
This summary is machine-generated.

Cells adapt to changing environments by filtering environmental signals. Saccharomyces cerevisiae

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Area of Science:

  • Cellular adaptation
  • Gene regulatory networks
  • Metabolic systems biology

Background:

  • Cells must adapt to dynamic environments for survival.
  • Gene-regulatory networks control cellular responses to environmental changes.
  • Understanding cellular adaptation requires dynamic environmental simulations.

Purpose of the Study:

  • To investigate Saccharomyces cerevisiae metabolic gene regulation under dynamic environmental conditions.
  • To determine how cells respond to periodic changes in carbon sources.
  • To compare the frequency response of different yeast strains.

Main Methods:

  • Utilized a microfluidic platform for precise control of dynamic environmental conditions.
  • Monitored metabolic gene regulation in Saccharomyces cerevisiae.
  • Employed computational modeling to predict and compare with experimental results.

Main Results:

  • The metabolic system functions as a low-pass filter, responding to slow environmental changes and ignoring rapid fluctuations.
  • Observed a faster-than-predicted low-frequency response attributed to carbon source-dependent transcript half-lives.
  • Identified conserved frequency response across yeast strains with differing induction properties.

Conclusions:

  • Saccharomyces cerevisiae metabolic networks are optimized for robust responses to dynamic environments.
  • Transcript half-life variability is crucial for accurate modeling of cellular adaptation.
  • Cellular systems exhibit optimized dynamic responses despite variations in static network characteristics.