[Atrial fibrillation--thromboembolism and prevention]

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Updated: Aug 12, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

P Petersen1, G Boysen, J Godtfredsen

  • 1Rigshospitalet, København, neuromedicinsk afdeling.

Ugeskrift for Laeger
|July 22, 1991
PubMed

Insights

Atrial fibrillation increases stroke risk, especially in those with prior heart attacks. Warfarin effectively reduces thromboembolic events, while aspirin

Area of Science:

  • Cardiology
  • Neurology
  • Pharmacology

Context:

  • Chronic non-rheumatic atrial fibrillation (AF) carries a significant annual risk of thromboembolic complications (approx. 5%).
  • Previous myocardial infarction is a key risk factor for thromboembolism in AF patients.
  • Silent cerebral infarction is more prevalent in chronic AF patients compared to those in sinus rhythm.

Purpose:

  • To evaluate the efficacy of anticoagulation therapies, specifically warfarin and aspirin, in preventing thromboembolic complications in patients with atrial fibrillation.
  • To assess the influence of patient demographics, such as age and history of myocardial infarction, on treatment outcomes.

Summary:

  • Warfarin demonstrated effectiveness in reducing thromboembolic complications across three prospective trials.
  • Aspirin (325 mg daily) showed efficacy only in patients under 75 years old; its effect was not observed in older patients or in other trials.
  • Paroxysmal and isolated AF in younger individuals may present a lower embolic risk.

Impact:

  • Provides evidence-based guidance on anticoagulation strategies for atrial fibrillation management.
  • Highlights the importance of risk stratification, considering factors like age and prior myocardial infarction, when selecting therapy.
  • Informs clinical decision-making regarding stroke prevention in diverse atrial fibrillation patient populations.

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