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Infections in gastroschisis: organisms and factors
B A Khalil1, M E Baath, C T Baillie
1Department of Paediatric Surgery, Royal Manchester Children's Hospital, Pendlebury, Manchester, M27 4HA, UK. Kba_bas@hotmail.co.uk
Pediatric Surgery International
|August 1, 2008
Summary
Infection in newborns with gastroschisis is often caused by abnormal gut bacteria, leading to wound infections. Strict protocols and multidisciplinary care are key to reducing newborn morbidity.
Area of Science:
- Neonatal Surgery
- Infectious Diseases in Neonates
- Gastrointestinal Abnormalities
Background:
- Gastroschisis presents significant challenges in neonatal care.
- Infection-related morbidity is a major concern for neonates with gastroschisis.
Purpose of the Study:
- To determine the incidence of infection-related morbidity in newborns with gastroschisis.
- To identify causative organisms and predisposing factors for these infections.
- To analyze factors influencing outcomes in gastroschisis patients.
Main Methods:
- Retrospective review of 72 gastroschisis patients (1999-2004).
- Analysis of surveillance samples, cultures (wound, blood, urine, fecal), and clinical data.
- Statistical analysis using multiple logistic regression (SPSS, p < 0.05).
Main Results:
- 53% of neonates had abnormal gut carriage (Enterobacter, Klebsiella).
- Wound infection (20%) was linked to abnormal gut carriage; line sepsis (21%) was primarily caused by Staphylococcus.
- Overall survival rate was 96%.
Conclusions:
- Infections in gastroschisis patients are multifactorial.
- Abnormal gut carriage is a risk factor for wound infections.
- Multidisciplinary teams, aseptic protocols, and auditing are crucial for reducing morbidity.
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