Related Experiment Video
Updated: Jul 3, 2026
08:45
Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
[Risk factors associated with multiple-species candidemia]
A Benetucci1, I N Tiraboschi, N Fernández
1División Infectología, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Av. Córdoba 2351, Piso 3 (1120) Ciudad Autónoma de Buenos Aires, Argentina. micologia@hospitaldeclinicas.uba.ar
Revista Argentina De Microbiologia
|August 2, 2008
Summary
Multiple-species candidemia (MSC) is rare but linked to longer hospital stays and central venous catheter use. Identifying and managing these risk factors is key to preventing severe fungal infections.
Area of Science:
- Infectious Diseases
- Mycology
- Hospital Epidemiology
Background:
- Fungal infections, specifically candidemia, have seen a rise in incidence.
- Multiple-species candidemia (MSC) is an uncommon but significant clinical presentation.
Purpose of the Study:
- To investigate the characteristics and risk factors associated with multiple-species candidemia.
- To compare outcomes of MSC with monomicrobial candidemia.
Main Methods:
- Retrospective case-control study.
- Analysis of 155 candidemia cases from 1998-2004.
- Comparison of 7 MSC cases with 21 monomicrobial candidemia cases.
Main Results:
- No significant differences in clinical data or outcomes between MSC and monomicrobial candidemia groups.
- MSC cases showed longer hospital stays (39 vs. 18 days).
- MSC cases had longer central venous catheter dwell times (32 vs. 12 days) and candidemia duration (5 vs. 1 day).
Conclusions:
- While infrequent, MSC is associated with prolonged hospitalization and central venous catheter use.
- Modifiable risk factors, including duration of hospital stay and catheter permanence, contribute to MSC development.
- Management strategies should focus on reducing these risk factors to prevent MSC.
Related Concept Videos
01:26Factors Affecting the Risk of Infection
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
01:20Candidiasis
Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
01:28Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
01:27Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
01:25Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
01:24Drug Toxicity: Risk factors
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...