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Diabetic glomerulosclerosis patients exhibit heightened blood coagulation and altered fibrinolysis. These changes are more severe in diabetes mellitus patients, suggesting a need for monitoring and potential heparin therapy.
Area of Science:
- Nephrology
- Endocrinology
- Hematology
Background:
- Diabetic glomerulosclerosis is a significant complication of diabetes mellitus.
- Alterations in coagulation and fibrinolysis are implicated in diabetic nephropathy progression.
Purpose of the Study:
- To investigate the hemostatic system in patients with diabetic glomerulosclerosis.
- To compare coagulation and fibrinolysis in diabetic patients with and without glomerulosclerosis.
Main Methods:
- Assessment of blood coagulation parameters.
- Evaluation of fibrinolysis system activity.
- Comparison between patient groups.
Main Results:
- Patients with diabetic glomerulosclerosis showed increased blood coagulation intensity.
- Diverse changes in the fibrinolysis system were observed.
- These hemostatic alterations were more pronounced in patients with diabetes mellitus and glomerulosclerosis.
Conclusions:
- Diabetic glomerulosclerosis is associated with significant hemostatic dysregulation.
- The Lejen method is recommended for guiding heparin therapy and monitoring anticoagulation in these patients.
Abstract:
It was found that patients with diabetic glomerulosclerosis showed an increased intensity of blood coagulation as well as essential diverse changes in the system of fibrinolysis. These changes were more pronounced in patients suffering of diabetes mellitus than in the diabetic patients without glomerulosclerosis. It is recommended to introduce into clinical practice the Lejen method with the purpose of determining indications to heparin therapy and dynamic control of patients during treatment with anticoagulants.