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Updated: Jul 3, 2026
Freezing Injury in Mouse Masseter Muscle to Establish an Orofacial Muscle Fibrosis Model
Published on: December 29, 2023
[Muscle-aponeurotic aggressive fibromatosis management. 10 years of experience]
Josué Antonio Miranda Roa1, Genaro Rico Martínez, Luis Miguel Linares González
1Instituto Nacional de Rehabilitación, Servicio de Tumores Oseos, Delegación Tlalpan, México, DF. miranda_roa@hotmail.com
Introduction:
This work presents clinical evolution and functional outcome of patients with histologic diagnosis of Muscle-aponeurotic aggressive fibromatosis in 10 years of follow up in the National Rehabilitation Institute.
Material And Methods:
We performed a descriptive, retrospective, cross sectioned clinical trial in the Bone Tumour Department. We reviewed the clinical and radiological files from 1996 to 2006.
Inclusion Criteria:
both genres, any age, clinical and histological diagnosis.
Exclusion Criteria:
incomplete file, lost to follow up, other diagnosis. Elimination criteria: Death during trial period. Analyzed variables. Age, genre, occupation, birth place, school degree, anatomic situation, signs and symptoms, time of follow up, treatment, relapses. We used statistical computed system Excel 2007, with central trend descriptive variables.
Results:
Eleven patients (mean age 24.36; SD 18.32, 1-61 years), 9 female (81.8%) 2 male; birth place: Mexico City 7 (63.63%), Puebla 1, Toluca 1, South Baja California 1 and Chiapas 1. Anatomic situation: Pelvis 6 (54.54%), thoracic and gluteus 3. Pain and presence of a mass 10 (90.9%), range of motion limitation 5, edema and erithema 1. Relapses 6 (55%).
Treatment:
broad resection 3 patients, marginal resection 6 patients, radical resection 2 patients.
Conclusions:
If clinical suspicion of Muscle-aponeurotic fibromatosis appears, one should start protocol work up: laboratory, radiographic assessment, nuclear medicine, biopsy and histologic and immune-histochemistry. One should perform broad resections aiming to preserve the most possible extremity tissue disease free.
