[Changes in the intracellular localization of viral antigens in influenza]

The authors studied intracellular location of the viral structures in the lung tissue in the acute period of infection (on the 3rd-6th after inoculation) and on the 28th day when the infectious virus failed to be detected. It was stated that on the 3rd and 6th day after the inoculation viral antigens were equally distributed between cytoplasmic and membraneous fractions. The 28th day demonstrated the presence of the antigens in cytoplasma and their absence in the cellular membranes of the lung. The results obtained could be used for specification of mechanisms of influenza virus persistence in the body.