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Updated: Jul 28, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
[Current problems of ante- and perinatal pathology]
Abstract:
The paper provides strong evidence for further postmortem investigations in the ante- and perinatal periods, in the combination of those of the afterbirth. The very early antenatal abnormalities (gametopathy and blastopathy) have been less studied. There are predominant congenital malformations of the organs concurrent with placental incompetence among embryopathies. In the fetal period, the authors identify an abnormality in the early fetal phase when placental insufficiency, fetal hypoxia and intrauterine death prevail; that in the mid fetal phase concomitant with infectious fetal injuries and acute and chronic placental failures due to maternal diseases; and that in the late fetal phase that covers perinatal death. The time course of reasons for stillbirth and neonatal death was analyzed in Moscow in 1986-1989. Etiological causes of early and late abortions have been identified, which is a real reserve of reduction in ante- and perinatal mortality rates in this country.
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