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Bipolar Disorder

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.

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Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

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Abnormal anterior cingulum integrity in bipolar disorder determined through diffusion tensor imaging.

Fei Wang¹, Marcel Jackowski, Jessica H Kalmar

¹Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA. fei.wang@yale.edu

The British Journal of Psychiatry : the Journal of Mental Science

|August 2, 2008

Summary

This summary is machine-generated.

Bipolar disorder is linked to reduced white matter integrity in the anterior cingulum. This study used diffusion tensor imaging to find these abnormalities in the brain

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Area of Science:

Neuroimaging
Neuroscience
Psychiatry

Background:

Convergent evidence suggests white matter abnormalities in bipolar disorder.
The cingulum is a key white matter tract within the emotional regulation network.

Purpose of the Study:

To investigate white matter integrity in the cingulum of individuals with bipolar disorder.
To test the hypothesis of abnormal cingulum white matter structure in bipolar disorder.

Main Methods:

Diffusion tensor imaging was used to assess white matter integrity.
Fractional anisotropy (FA) was measured in the anterior and posterior cingulum.
42 participants with bipolar disorder were compared to 42 healthy controls.

Main Results:

Significantly decreased fractional anisotropy was observed in the anterior cingulum of the bipolar disorder group (P=0.003).
No significant differences in fractional anisotropy were found in the posterior cingulum between groups.

Conclusions:

The findings indicate structural abnormalities in the anterior cingulum in bipolar disorder.
This supports the involvement of the anterior cingulate cortex and its white matter connections in the disorder.