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713A, a new metabolite isolated from a fungal strain 713
Ying-shu Zou1, Ke Wang, Yang Zhang
1Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China.
Chemical & Pharmaceutical Bulletin
|August 2, 2008
Abstract:
A new compound named 713A was isolated from the fermentation broth of a fungal strain 713. The structure of 713A was elucidated by spectroscopic methods. In the screening for interleukin-6 (IL-6) receptor antagonist, 713A exhibited inhibitory activity to the binding of IL-6 and IL-6 receptor with an IC50 value of 8.6 microM.
