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Prolonged toxicity after massive olanzapine overdose: two cases with confirmatory laboratory data
The Journal of Toxicological Sciences
|August 2, 2008
Summary
Massive olanzapine overdose can cause prolonged coma and respiratory depression, requiring ventilatory support. Despite extremely high serum concentrations, patients recovered fully with supportive care, highlighting olanzapine
Area of Science:
- Pharmacology
- Toxicology
- Clinical Medicine
Background:
- Olanzapine, a second-generation antipsychotic, is widely prescribed.
- Data on severe olanzapine toxicity from overdose is limited.
Observation:
- Two patients experienced coma and respiratory depression after massive olanzapine ingestion.
- Prolonged ventilatory support was necessary for both individuals.
Findings:
- Serum olanzapine levels were significantly elevated, exceeding therapeutic ranges by orders of magnitude.
- Drug concentrations remained high for several days post-ingestion.
- Both patients achieved full recovery solely with supportive care.
Implications:
- Olanzapine overdose can lead to severe, prolonged central nervous system depression.
- Supportive care is effective in managing severe olanzapine toxicity.
- Clinicians should be aware of the potential for delayed recovery in significant olanzapine ingestions.
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