Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A test of a conceptual model of uncertainty, benefit and burden in children and young people with juvenile dermatomyositis.

Rheumatology advances in practice·2026
Same author

Working With School-Aged Children With Neurodisability and Oropharyngeal Dysphagia Who Require Mealtime Assistance: A Survey of Speech and Language Therapists' Clinical Practice.

International journal of language & communication disorders·2026
Same author

Barriers and enablers to shared decision-making in assessment and management of risk: A qualitative interview study with people using mental health services.

PLOS mental health·2026
Same author

Mealtime interventions for carers of school-aged children who have oropharyngeal dysphagia: A systematic review.

International journal of speech-language pathology·2026
Same author

Statin Effects on Pericoronary Adipose Tissue Density in People With HIV: Insights From the REPRIEVE Trial.

JACC. Cardiovascular imaging·2025
Same author

A Novel Digital Intervention to Facilitate Diabetes Self-Management Among People with Schizophrenia and Related Disorders: Development and Acceptability Testing of SMART.

Neuropsychiatric disease and treatment·2025

Related Experiment Video

Updated: Jul 3, 2026

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry
09:38

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry

Published on: June 26, 2019

Genetic analysis implicates resistin in HIV lipodystrophy.

Koustubh Ranade1, William J Geese, Mustafa Noor

  • 1Bristol-Myers Squibb R&D, Princeton, New Jersey 08543-5400, USA. koustubh.ranade@bms.com

AIDS (London, England)
|August 2, 2008
PubMed
Summary

Genetic variations in the resistin gene increase the risk of metabolic complications, such as elevated lipids and insulin resistance, in patients receiving highly active antiretroviral therapy (HAART). This finding aids in personalized treatment strategies.

More Related Videos

Peptide-based Identification of Functional Motifs and their Binding Partners
14:28

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
14:23

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

Published on: August 31, 2014

Related Experiment Videos

Last Updated: Jul 3, 2026

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry
09:38

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry

Published on: June 26, 2019

Peptide-based Identification of Functional Motifs and their Binding Partners
14:28

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
14:23

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

Published on: August 31, 2014

Area of Science:

  • Genetics
  • Metabolic Disorders
  • Pharmacogenomics

Background:

  • Highly active antiretroviral therapy (HAART) can lead to metabolic complications.
  • Identifying individuals at higher risk for these complications is crucial for personalized medicine.

Purpose of the Study:

  • To explore the genetic factors influencing metabolic complications in patients undergoing HAART.
  • To identify specific genetic variations associated with increased risk of metabolic abnormalities.

Main Methods:

  • Cluster analysis of metabolic traits in 189 patients from the ACTG5005s study.
  • Screening of nearly 300 single nucleotide polymorphisms (SNPs) in 135 candidate genes.
  • Association analysis between genetic variations and a high-risk subgroup for metabolic complications.

Main Results:

  • A subgroup of patients developed elevated lipids and insulin resistance on HAART, despite a normal baseline metabolic profile.
  • This high-risk group experienced significant body composition changes, including limb fat loss.
  • A specific SNP in the resistin gene was significantly associated with this high-risk group (P = 0.0003).

Conclusions:

  • Genetic variations in the resistin gene are linked to HAART-induced metabolic complications.
  • Resistin gene variations may serve as a biomarker for predicting metabolic risk in patients on HAART.
  • These findings support the role of pharmacogenomics in managing HAART-related adverse events.