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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: Jul 3, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

Gene therapy in bladder cancer.

Bernard H Bochner1

  • 1Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer , New York, New York 10021, USA. bochnerb@mskcc.org

Current Opinion in Urology
|August 2, 2008
PubMed
Summary

Viral gene therapy shows promise for bladder cancer treatment, with recent studies demonstrating feasibility and improved delivery methods. Further research into gene delivery and vector safety is needed for clinical application.

Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Therapy

Background:

  • Gene therapy offers a promising avenue for cancer treatment.
  • Bladder cancer is a suitable target due to accessible tumor sites.
  • Various gene therapy strategies have been explored for bladder tumors.

Purpose of the Study:

  • To review recent outcomes of viral-based gene therapy for bladder cancer.
  • To highlight advancements in gene delivery and therapeutic strategies.

Main Methods:

  • Review of preclinical in-vitro and in-vivo studies.
  • Analysis of recent research on viral vector systems for bladder transfection.
  • Evaluation of improved targeting techniques for transgene delivery.

Main Results:

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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

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Last Updated: Jul 3, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
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An Orthotopic Bladder Cancer Model for Gene Delivery Studies

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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

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  • Intravesical viral-mediated gene therapy is feasible.
  • New viral systems enhance bladder tumor transfection.
  • Advanced targeting improves transgene delivery.
  • Gene corrective treatment, enzyme prodrug therapy, and immunomodulation show positive results.

Conclusions:

  • Viral gene therapy is a potential future treatment for bladder cancer.
  • Enhancements in gene delivery and vector safety are crucial for clinical translation.
  • Further research is required to move this therapy from laboratory to clinical settings.