Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diurnal Curve of the Ocular Perfusion Pressure.

Journal of current glaucoma practice·2016
Same author

Factors associated with topographic changes of the optic nerve head induced by acute intraocular pressure reduction in glaucoma patients.

Eye (London, England)·2010
Same author

A comparison between microperimetry and standard achromatic perimetry of the central visual field in eyes with glaucomatous paracentral visual-field defects.

The British journal of ophthalmology·2009
Same author

Retinal vascular occlusions occur more frequently in the more affected eye in exfoliation syndrome.

Eye (London, England)·2009
Same author

Monocular diplopia induced by posterior chamber intraocular lens in a patient with peripheral laser iridotomy: a case report.

Eye (London, England)·2008
Same author

Imaging of a traumatic cyclodialysis cleft in a child using slit-lamp-adapted optical coherence tomography.

Eye (London, England)·2008
Same journal

Tubing the trabeculectomy: a novel filtration technique.

Eye (London, England)·2026
Same journal

Retinal non-perfusion progression in severe non-proliferative and proliferative diabetic retinopathy over time: INSPIRED study report 2.

Eye (London, England)·2026
Same journal

Macular serpiginous choroiditis versus macular serpiginous-like choroiditis: clinical features, outcomes and prognosis.

Eye (London, England)·2026
Same journal

Association of baseline brain care score with the incidence of age-related eye diseases.

Eye (London, England)·2026
Same journal

A comparative analysis of carbon dioxide versus nitrous oxide as the pressurised gas driving a retinal cryotherapy unit.

Eye (London, England)·2026
Same journal

Determinants of regression kinetics in observed stage 3 retinopathy of prematurity without plus disease.

Eye (London, England)·2026
See all related articles

Related Experiment Video

Updated: Jul 3, 2026

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
07:00

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Published on: October 5, 2018

Changes in visual function after intraocular pressure reduction using antiglaucoma medications.

T S Prata1, M V Piassi, L A S Melo

  • 1Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil. tiagoprata@oftalmo.epm.br

Eye (London, England)
|August 2, 2008
PubMed
Summary
This summary is machine-generated.

Glaucoma treatment improved visual function, including visual quality and contrast sensitivity, but did not correlate with intraocular pressure reduction. Three common glaucoma medications showed similar visual function outcomes.

More Related Videos

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Related Experiment Videos

Last Updated: Jul 3, 2026

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
07:00

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Published on: October 5, 2018

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Area of Science:

  • Ophthalmology
  • Clinical Trials
  • Glaucoma Research

Background:

  • Primary open-angle glaucoma is a leading cause of irreversible blindness.
  • Effective management involves lowering intraocular pressure (IOP) to prevent optic nerve damage.
  • The impact of initial glaucoma treatment on visual function requires further investigation.

Purpose of the Study:

  • To assess changes in visual function following the initiation of glaucoma treatment.
  • To correlate visual function improvements with intraocular pressure (IOP) reduction.
  • To compare the efficacy of three different glaucoma medications on visual function.

Main Methods:

  • A prospective, randomized clinical trial involving 54 primary open-angle glaucoma patients.
  • Patients received one of three topical medications: timolol maleate, brimonidine tartrate, or travoprost.
  • Visual function was evaluated using standard automated perimetry (SAP), contrast sensitivity (CS), and visual quality perception before and after a 4-week treatment period.

Main Results:

  • Statistically significant improvements were observed in IOP, SAP mean deviation index, visual quality perception, and contrast sensitivity after 4 weeks of treatment.
  • No significant differences in visual function changes were found among the three treatment groups.
  • No significant correlations were identified between the reduction in IOP and the observed changes in visual function.

Conclusions:

  • Initiating glaucoma therapy leads to improvements in visual quality perception, visual field indices, and contrast sensitivity.
  • The degree of intraocular pressure reduction does not correlate with improvements in visual function.
  • The three studied glaucoma medications demonstrated comparable effects on visual function.