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Published on: March 29, 2017

PPAR Regulation of Inflammatory Signaling in CNS Diseases

John J Bright1, Saravanan Kanakasabai, Wanida Chearwae

  • 1Neuroscience Research Laboratory, Methodist Research Institute, Clarian Health, Indianapolis, IN 46202, USA.

PPAR Research
|August 2, 2008
PubMed

Insights

Peroxisome proliferator-activated receptors (PPARs) regulate immune responses and show promise in treating neuroinflammatory diseases like multiple sclerosis and Alzheimer's by modulating inflammatory pathways in the central nervous system (CNS).

Area of Science:

  • Neuroimmunology
  • Molecular Endocrinology

Background:

  • The central nervous system (CNS) is typically immune privileged, but inflammation is implicated in various CNS diseases.
  • Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that control immune and inflammatory processes.

Purpose of the Study:

  • To review the current understanding of how PPARs influence neuroinflammatory signaling networks in CNS diseases.
  • To highlight the therapeutic potential of PPAR agonists in treating neuroinflammatory conditions.

Main Methods:

  • Literature review of studies investigating PPARs and neuroinflammation.
  • Analysis of PPAR isoform-specific effects (alpha, gamma, delta) in animal models of CNS diseases.
  • Examination of PPARs' modulation of key inflammatory pathways like NF-kappaB and Jak-Stat.

Main Results:

  • PPAR agonists have demonstrated efficacy in animal models of multiple sclerosis, Alzheimer's disease, Parkinson's disease, and stroke.
  • PPARs modulate inflammatory signaling networks within immune cells, impacting CNS disease pathogenesis.
  • Specific PPAR isoforms (alpha, gamma, delta) offer potential therapeutic targets for neuroinflammatory diseases.

Conclusions:

  • PPARs represent a promising therapeutic target for neuroinflammatory diseases.
  • Modulating PPAR activity can mitigate CNS disease progression by controlling inflammatory signaling.
  • Further research into PPAR agonists could lead to novel treatments for conditions involving neuroinflammation.

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