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Serotypes and susceptibility of Streptococcus pneumoniae strains isolated from children in Mexico

Alberto Villaseñor-Sierra1, Maricarmen Lomas-Bautista, Sergio Aguilar-Benavides

  • 1Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Mexico. avillase@prodigy.net.mx

Salud Publica De Mexico
|August 2, 2008
PubMed
Abstract

Insights

A 10-valent conjugate vaccine could cover most invasive Streptococcus pneumoniae meningeal strains identified in children. Serotypes 19F, 3, 6B, 14, and 23F were most common in invasive meningeal infections.

Area of Science:

  • Microbiology
  • Pediatric Infectious Diseases
  • Vaccinology

Background:

  • Streptococcus pneumoniae causes invasive infections in children.
  • Understanding serotype distribution and antimicrobial resistance is crucial for prevention strategies.

Purpose of the Study:

  • To determine the serotypes and antimicrobial susceptibility of S. pneumoniae strains from children with invasive infections and carriers.
  • To inform vaccine development and public health interventions.

Main Methods:

  • Serotyping was conducted using the Quellung reaction.
  • Antimicrobial susceptibility testing employed Kirby-Bauer and Etest methods, adhering to CLSI standards.

Main Results:

  • Predominant serotypes in meningeal infections included 19F, 3, 6B, 14, and 23F, with 16% penicillin and 58% trimethoprim-sulfamethoxazole (STX) resistance.
  • Non-meningeal invasive strains showed serotypes 19F and 3 predominance, with 0% penicillin and 82% STX resistance.
  • Carrier strains frequently exhibited serotypes 6A, 6B, 19F, and 23F.

Conclusions:

  • A 10-valent conjugate vaccine could provide enhanced coverage for prevalent meningeal S. pneumoniae serotypes.
  • Findings highlight the importance of serotype surveillance for effective vaccine strategies.

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