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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

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Related Experiment Video

Updated: Jul 3, 2026

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
11:32

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

Published on: January 3, 2025

Cell-based therapy in ischemic stroke.

David C Hess1, Cesar V Borlongan

  • 1Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA. dhess@mail.mcg.edu

Expert Review of Neurotherapeutics
|August 2, 2008
PubMed
Summary
This summary is machine-generated.

Cell-based therapy offers a new restorative approach for stroke, utilizing bone marrow or perinatal cells within weeks or months post-stroke for brain repair. Allogeneic cells show commercial viability, necessitating integrated clinical and preclinical research.

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Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
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Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

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Last Updated: Jul 3, 2026

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
11:32

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

Published on: January 3, 2025

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
14:53

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

Area of Science:

  • Regenerative Medicine
  • Neuroscience
  • Translational Stroke Research

Background:

  • Cell-based therapy represents a significant advancement in stroke treatment, shifting focus towards restorative processes.
  • Unlike neuroprotective therapies with narrow time windows, cell therapy offers extended opportunities for intervention.

Purpose of the Study:

  • To explore the potential of cell-based therapies for stroke, considering different time windows and cell types.
  • To highlight the importance of allogeneic cells for scalability and commercial viability.
  • To emphasize the need for an integrated approach combining clinical trials and preclinical research.

Main Methods:

  • Review of current research on cell-based therapies for stroke.
  • Analysis of early (intravenous) and late (intracerebral) therapeutic windows.
  • Consideration of different cell sources, including bone marrow and perinatal cells.
  • Discussion on the potential of allogeneic cell products.

Main Results:

  • Intravenously delivered bone marrow and perinatal cells show promise for early stroke intervention (within the first week) by targeting tissue injury and remodeling.
  • Later therapeutic windows (months post-stroke) may benefit from intracerebral transplantation of neuronally differentiated cells.
  • Allogeneic cells are identified as a scalable and commercially viable option for cell-based stroke therapy.

Conclusions:

  • Cell-based therapy is a promising third wave of stroke therapeutics focused on restoration.
  • An integrated strategy involving early clinical trials and preclinical mechanistic studies is crucial for advancing cell-based stroke treatments.
  • Both early and late therapeutic windows present unique opportunities for different cell-based approaches.