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Related Concept Videos

Toxoplasmosis01:28

Toxoplasmosis

Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...
American Trypanosomiasis01:22

American Trypanosomiasis

Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Trichomoniasis01:18

Trichomoniasis

Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, one of the most prevalent non-viral sexually transmitted infections in the United States. This extracellular parasite primarily colonizes the lower genitourinary tract in women—particularly the vagina—and in men, the urethra and prostate. Its structural and functional adaptations enable its survival, motility, and pathogenicity within the host environment.Structural Features and Host EntryT.
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...

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Related Experiment Video

Updated: Jul 3, 2026

Determination of Chemical Inhibitor Efficiency against Intracellular Toxoplasma Gondii Growth Using a Luciferase-Based Growth Assay
09:49

Determination of Chemical Inhibitor Efficiency against Intracellular Toxoplasma Gondii Growth Using a Luciferase-Based Growth Assay

Published on: April 29, 2020

Toxoplasma: the next 100years.

Kami Kim1, Louis M Weiss

  • 1Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA. kkim@aecom.yu.edu

Microbes and Infection
|August 2, 2008
PubMed
Summary
This summary is machine-generated.

Toxoplasma gondii, a common parasite, affects warm-blooded animals and causes serious diseases. Recent studies use advanced methods to explore its biology and host interactions.

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3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii
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3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii

Published on: December 9, 2014

Related Experiment Videos

Last Updated: Jul 3, 2026

Determination of Chemical Inhibitor Efficiency against Intracellular Toxoplasma Gondii Growth Using a Luciferase-Based Growth Assay
09:49

Determination of Chemical Inhibitor Efficiency against Intracellular Toxoplasma Gondii Growth Using a Luciferase-Based Growth Assay

Published on: April 29, 2020

3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii
06:33

3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii

Published on: December 9, 2014

Area of Science:

  • Parasitology
  • Infectious Diseases
  • Molecular Biology

Background:

  • Toxoplasma gondii, an Apicomplexan parasite, was first described in 1908.
  • It infects warm-blooded animals, causing conditions like encephalitis and congenital infections.
  • T. gondii serves as a model organism for studying intracellular pathogens due to available experimental techniques.

Purpose of the Study:

  • To review recent advances in understanding T. gondii's developmental biology.
  • To explore recent progress in T. gondii's host-pathogen interactions.

Main Methods:

  • Genome-wide expression studies
  • Chromatin immunoprecipitation on chip (ChIP-on-chip)
  • Proteomics surveys

Main Results:

  • These studies are refining our understanding of T. gondii's genetic networks.
  • New data is clarifying the developmental biology of the parasite.
  • Insights into host-parasite interactions are being gained.

Conclusions:

  • Recent research has significantly advanced the study of T. gondii.
  • Understanding T. gondii's biology and host interactions is crucial for disease control.