Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Toxoplasmosis01:28

Toxoplasmosis

Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...
Microbial Interactions: Parasitism01:22

Microbial Interactions: Parasitism

Parasitism is a form of microbial interaction in which parasitic microbes exploit a host organism for nutrients and shelter, often at the host's expense. Unlike mutualistic relationships, where both organisms benefit, parasitism benefits only the parasite and harms the host.Classification of ParasitesMicrobial parasites are broadly classified based on their location relative to the host.Ectoparasites remain on the host’s surface, such as the skin or outer tissues, drawing nutrients...
Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
Colonisation of Pathogens01:25

Colonisation of Pathogens

Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...
Amebiasis01:28

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
Diversity of Protists II01:27

Diversity of Protists II

Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Large-scale discovery platform enables identification of peptides targeting drug-resistant candidiasis.

Cell reports methods·2026
Same author

Fungal Extracellular Vesicles are Recoverable Across Variable Ultracentrifugation Speeds but Display Species-specific Profiles of Sedimentation.

The Journal of membrane biology·2026
Same author

Intracellular acidification by microbiota-derived valeric acid facilitates trans-kingdom ecology limiting Candida parapsilosis colonization.

Cell host & microbe·2026
Same author

Are CD4<sup>+</sup> T-Cell Counts Associated with <i>Pneumocystis jirovecii</i> Detection in Hospitalized Patients with Liver Disease? A Retrospective Exploratory Pilot Analysis.

Livers·2026
Same author

Empowering fungal infection research with single-cell RNA sequencing.

Communications biology·2026
Same author

The iron-responsive transcription factor HapX drives iron starvation adaptation and virulence in <i>Talaromyces marneffei</i>.

Current research in microbial sciences·2026
Same journal

The extent of monocytic myeloid suppressor cells induction determines the host immune response during Mycobacterium avium infection.

Microbes and infection·2025
Same journal

Culture-attenuated pathogenic Leptospira lose the ability to survive complement lytic activity due to decreased C4BP uptake.

Microbes and infection·2025
Same journal

Exploring the link between genetically predicted plasma cathepsins and COVID-19: A mendelian randomization study of susceptibility and severity.

Microbes and infection·2025
Same journal

Laboratory parameters and serum tube agglutination test as markers for brucellosis treatment response.

Microbes and infection·2025
Same journal

Corrigendum to "Lactococcus lactis and Bifidobacterium longum attenuate Clostridioides difficile- or Clostridium symbiosum-induced colitis and depression/anxiety-like behavior in male mice" [Microb Infect 27(7) (2025) 105560].

Microbes and infection·2025
Same journal

Disrupted Microbiome-Metabolome networks underlie gut barrier and immune imbalance in severe fever with thrombocytopenia syndrome.

Microbes and infection·2025
See all related articles

Related Experiment Video

Updated: Jul 3, 2026

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
13:56

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

Histoplasma capsulatum at the host-pathogen interface.

Joshua D Nosanchuk1, Attila Gacser

  • 1Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA. nosanchu@aecom.yu.edu

Microbes and Infection
|August 2, 2008
PubMed
Summary
This summary is machine-generated.

Histoplasma capsulatum causes invasive pulmonary fungal disease, particularly in immunocompromised individuals. Advances in studying its pathogenesis offer improved strategies to combat this common infection.

More Related Videos

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens
09:57

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Published on: February 14, 2011

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
14:58

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions

Published on: March 5, 2022

Related Experiment Videos

Last Updated: Jul 3, 2026

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
13:56

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens
09:57

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Published on: February 14, 2011

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
14:58

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions

Published on: March 5, 2022

Area of Science:

  • Mycology
  • Infectious Diseases
  • Immunology

Background:

  • Histoplasma capsulatum is a globally prevalent cause of invasive pulmonary fungal disease.
  • Severe histoplasmosis disproportionately affects immunocompromised individuals.
  • The use of immunomodulators increases the risk of latent histoplasmosis reactivation.

Purpose of the Study:

  • To review the complex host-pathogen interactions of Histoplasma capsulatum.
  • To highlight recent advancements in understanding Histoplasma capsulatum pathogenesis.
  • To discuss the implications for managing histoplasmosis in at-risk populations.

Main Methods:

  • Review of current literature on Histoplasma capsulatum.
  • Analysis of host-pathogen interactions.
  • Evaluation of molecular tools and animal models for virulence studies.

Main Results:

  • Histoplasma capsulatum pathogenesis is a dynamic host-pathogen interaction.
  • Immunocompromised states and immunomodulator use elevate disease severity and reactivation risk.
  • Developed molecular tools and animal models facilitate virulence research.

Conclusions:

  • Recent advances in understanding Histoplasma capsulatum pathogenesis are improving disease management strategies.
  • Continued research is crucial for combating invasive fungal pulmonary disease caused by Histoplasma capsulatum.
  • Enhanced knowledge of virulence factors will improve therapeutic interventions.