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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Loss of Tumor Suppressor Gene Functions01:12

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Loss of Tumor Suppressor Gene Functions01:12

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Familial melanoma.

Johan Hansson1

  • 1Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institute, Karolinska University Hospital Solna, S-17176 Stockholm, Sweden. johan.hansson@ki.se

The Surgical Clinics of North America
|August 2, 2008
PubMed
Summary
This summary is machine-generated.

Hereditary melanoma, often linked to CDKN2A gene mutations, increases cancer risk. Genetic testing and management guidelines are crucial for affected families with melanoma and pancreatic cancer risks.

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Area of Science:

  • Genetics
  • Oncology
  • Dermatology

Background:

  • Familial melanoma accounts for 5-10% of cases.
  • Germline CDKN2A mutations are found in 20-40% of these families.
  • Some families with hereditary melanoma also have increased pancreatic cancer risk.

Purpose of the Study:

  • To discuss management guidelines for familial melanoma.
  • To address genetic testing for CDKN2A germline mutations.

Main Methods:

  • Review of existing literature and clinical guidelines.
  • Analysis of familial melanoma case data and genetic testing outcomes.

Main Results:

  • CDKN2A mutations are a significant factor in hereditary melanoma.
  • Increased risk for both melanoma and pancreatic cancer in affected kindreds.
  • Genetic testing can identify at-risk individuals.

Conclusions:

  • Management of familial melanoma requires consideration of genetic predisposition.
  • Genetic testing for CDKN2A mutations is important for risk assessment and management.
  • Multidisciplinary care is recommended for families with hereditary melanoma and pancreatic cancer.