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The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
Investigating tuberculosis trends in England
J P Crofts1, D Gelb, N Andrews
1Respiratory Diseases Department, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK.
Public Health
|August 2, 2008
Summary
Tuberculosis incidence in England rose by 19% due to increased cases among recent non-UK born immigrants and those with human immunodeficiency virus (HIV). Migration is the primary driver of these trends.
Area of Science:
- Epidemiology
- Infectious Diseases
- Public Health
Background:
- Tuberculosis (TB) incidence in England has shown an upward trend.
- Understanding the drivers of this increase is crucial for effective public health interventions.
Purpose of the Study:
- To investigate the demographic, clinical, and microbiological factors contributing to the rising incidence of tuberculosis in England between 1999 and 2003.
Main Methods:
- A prospective national surveillance study was conducted.
- Relative trends in TB case characteristics were measured over a five-year period.
Main Results:
- Tuberculosis cases increased by 19% from 5539 to 6608 between 1999 and 2003.
- Significant increases were observed in non-UK-born recent entrants and tuberculosis cases co-infected with human immunodeficiency virus (HIV).
- Increases in isoniazid-resistant and multi-drug-resistant tuberculosis were noted in London.
Conclusions:
- While TB remains linked to deprivation, migration is the main factor explaining recent incidence trends in England.
- The proportion of TB cases co-infected with HIV has risen.
- Targeting latent tuberculosis infection alongside active disease measures is recommended to reduce UK incidence.
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