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Updated: Jul 3, 2026
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Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance
Published on: August 25, 2021
Perforating globe injuries during operation Iraqi Freedom.
Marcus H Colyer1, Dal W Chun, Kraig S Bower
1Ophthalmology Service, Walter Reed Army Medical Center, Washington, DC, USA.
Ophthalmology
|August 2, 2008
Summary
Combat ocular trauma (COT) involving perforating globe injuries often leads to poor visual outcomes. While eye protection can prevent these injuries, advanced treatments are needed to improve vision and anatomy.
Area of Science:
- Ophthalmology
- Trauma Surgery
- Military Medicine
Background:
- Combat ocular trauma (COT) presents significant challenges in visual restoration.
- Perforating globe injuries are a severe subset of COT with high rates of visual impairment.
Purpose of the Study:
- To analyze injury patterns and visual outcomes of perforating globe injuries in soldiers.
- To evaluate the effectiveness of surgical interventions for combat-related ocular trauma.
Main Methods:
- Retrospective case series of 65 eyes from 61 soldiers treated at WRAMC.
- Data collected on injury patterns, surgical procedures (enucleation, vitrectomy), and visual acuity.
Main Results:
- Median presenting visual acuity was no light perception; final visual acuity remained poor for most.
- Anterior globe injuries correlated with better anatomic and visual outcomes.
- Proliferative vitreoretinopathy occurred in 61% of pars plana vitrectomy cases.
Conclusions:
- Perforating globe injuries in COT typically result in poor visual and anatomic outcomes.
- Eye protection is crucial for prevention, but novel therapies are needed for better outcomes.
- Further research into advanced surgical and pharmacologic treatments is warranted.
