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Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

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The Skin Microbiota

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Updated: Jul 3, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Atopic dermatitis complicated by methicillin-resistant Staphylococcus aureus infection.

Kam-Lun Ellis Hon1, Alexander K C Leung, Albert Y F Kong

  • 1Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China. ehon@cuhk.edu.hk

Journal of the National Medical Association
|August 5, 2008
PubMed
Summary

Methicillin-resistant Staphylococcus aureus (MRSA) can cause severe atopic dermatitis in children. Early screening for MRSA is crucial, as vancomycin effectively treats infections, resolving symptoms like erythema and odor.

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Last Updated: Jul 3, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Area of Science:

  • Pediatric Dermatology
  • Infectious Diseases
  • Microbiology

Background:

  • Staphylococcus aureus colonization is linked to atopic dermatitis severity in children.
  • This report reviews five pediatric cases of methicillin-resistant S. aureus (MRSA) with moderate-to-severe atopic dermatitis.
  • Patients presented with severe, long-standing disease, elevated IgE and eosinophils.

Purpose of the Study:

  • To describe clinical characteristics and treatment outcomes of MRSA in children with atopic dermatitis.
  • To highlight potential diagnostic indicators of MRSA infection in this population.

Main Methods:

  • Retrospective chart review of five pediatric patients diagnosed with MRSA between 2004-2007.
  • Analysis of clinical presentation, laboratory findings, and treatment responses.

Main Results:

  • Generalized erythema and a distinct fishy odor were frequently noted during MRSA exacerbations.
  • Patients had failed multiple prior treatments, including steroids and antibiotics.
  • All MRSA isolates were sensitive to vancomycin, with treatment leading to symptom resolution.

Conclusions:

  • A fishy odor and erythema in pediatric atopic dermatitis warrant MRSA screening.
  • MRSA is infrequently isolated but treatable with vancomycin, which resolves associated symptoms.