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Published on: June 5, 2019

[Effect of xinkeshu tablet on heart rate variability in patients with coronary heart disease]

Qian Zang1, Jiang-Yun Zhou, Ning-Ling Sun

  • 1Center of Cardiology, Beijing People's Hospital Affiliated to Peking University, Beijing. zq@medmail.com.cn

Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine
|August 5, 2008
PubMed

Insights

Xinkeshu Tablet (XKS) improved heart rate variability (HRV) and reduced angina episodes in coronary heart disease (CHD) patients. Metoprolol also showed benefits, but XKS demonstrated more significant improvements in certain HRV frequency-domain indexes.

Area of Science:

  • Cardiology
  • Pharmacology
  • Medical Research

Context:

  • Coronary heart disease (CHD) poses significant cardiovascular risks.
  • Heart rate variability (HRV) is a crucial indicator of autonomic nervous system function in cardiovascular health.
  • Traditional treatments for CHD aim to manage symptoms and improve cardiac function.

Purpose:

  • To investigate the therapeutic effect of Xinkeshu Tablet (XKS) on HRV in patients diagnosed with CHD.
  • To compare the efficacy of XKS with Metoprolol, a standard beta-blocker, in managing CHD symptoms and HRV.

Summary:

  • Sixty CHD patients were randomized to receive either XKS or Metoprolol alongside conventional treatment for 8 weeks.
  • Both groups experienced a reduction in angina pectoris episodes and a decrease in average heart rate.
  • Xinkeshu Tablet (XKS) treatment resulted in more significant improvements in specific frequency-domain HRV indexes compared to Metoprolol.

Impact:

  • Xinkeshu Tablet (XKS) demonstrates potential as an adjunctive therapy for improving autonomic function in CHD patients.
  • The findings suggest XKS may offer superior benefits in modulating cardiac autonomic balance compared to Metoprolol.
  • This study contributes to understanding novel therapeutic strategies for managing coronary heart disease.
Abstract

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