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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...

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Related Experiment Video

Updated: Jul 3, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
11:14

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

Wnt signaling in angiogenesis.

Nancy L Parmalee1, Jan Kitajewski

  • 1Department of Genetics and Development, Irving Research Center, NY, NY 10032, USA.

Current Drug Targets
|August 5, 2008
PubMed
Summary

Wnt signaling, crucial for blood vessel formation (angiogenesis), involves Frizzled receptors. Norrin, a novel Wnt factor, utilizes Frizzled4 to promote vascular growth, particularly in the retina.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Vascular Biology

Background:

  • Angiogenesis research has advanced, yet the role of Wnt growth factors in vasculature remains unclear.
  • Wnt factors and Frizzled receptors regulate key cellular processes like proliferation, apoptosis, and morphogenesis.
  • These processes are vital for the development and maintenance of vascular structures.

Purpose of the Study:

  • To review the angiogenic functions of Wnt signaling in the vasculature.
  • To highlight the role of Norrin, a newly identified angiogenic factor.
  • To discuss Norrin's mechanism of action via the Frizzled4 receptor.

Main Methods:

  • Literature review of Wnt signaling in angiogenesis.
  • Analysis of studies on vascular growth in murine and human retina.

More Related Videos

Modified In Vivo Matrix Gel Plug Assay for Angiogenesis Studies
09:03

Modified In Vivo Matrix Gel Plug Assay for Angiogenesis Studies

Published on: June 30, 2023

Related Experiment Videos

Last Updated: Jul 3, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
11:14

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

Modified In Vivo Matrix Gel Plug Assay for Angiogenesis Studies
09:03

Modified In Vivo Matrix Gel Plug Assay for Angiogenesis Studies

Published on: June 30, 2023

  • Focus on the interaction between Norrin and Frizzled4.

    • Main Results:

    • Wnt/Frizzled signaling is implicated in proper vascular growth, evidenced in retinal studies.
    • Norrin has been identified as a significant angiogenic factor.
    • Norrin specifically acts through the Wnt receptor, Frizzled4.

    Conclusions:

    • Wnt signaling pathways are critical for vascular development and angiogenesis.
    • Norrin represents a key Wnt-mediated regulator of vascular growth.
    • Targeting the Norrin/Frizzled4 interaction may offer therapeutic potential for angiogenesis-related disorders.