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Updated: Jul 3, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Interactions of beta- and hydroxypropyl-beta-cyclodextrin with some purine alkaloids: thermodynamic study
1Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya Str., Ivanovo, Russian Federation. ivt@isc-ras.ru
Abstract:
The effect of native and hydroxypropylated beta-cyclodextrin on the solubility and activity of some purine alkaloids was examined. For this purpose, the solubility of purine alkaloids in pure water and in aqueous solutions of mentioned beta-cyclodextrins was determined at 298.15 K. Stability constants of inclusion complexes and their stoichiometry were obtained from solubility diagrams. Enthalpic characteristics of interactions occurring between beta-cyclodextrins and purine alkaloids in aqueous solution were calculated from the direct calorimetric measurements. It was found, that beta-cyclodextrin forms with purine alkaloids weak complexes which are stabilized only by the entropy term. Due to very low complexing affinity of both beta-cyclodextrins to studied purine alkaloids their solubilizing effect is insignificant. The influence of structure of purine alkaloids and beta-cyclodextrin on the thermodynamic parameters of interaction was discussed.
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