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Published on: February 8, 2017
Colon targeted drug delivery systems--an overview.
1Department of Pharmaceutics Institute of Technology Banaras Hindu University, Varanasi-221005, India. pramod_79kumar@rediffmail.com
Current Drug Delivery
|August 5, 2008
Summary
Colon targeted drug delivery systems protect medications in the upper GI tract for effective treatment of colon diseases. Newer systems show improved site specificity and release kinetics compared to traditional methods.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Gastroenterology
Background:
- Colon targeted drug delivery is crucial for treating colonic diseases and delivering biologics.
- Traditional methods (prodrugs, pH, time, microflora-activated) have shown limited success.
- Effective colon targeting requires protecting drugs from the upper GI tract and ensuring abrupt release in the colon.
Purpose of the Study:
- To review various colon targeted drug delivery systems.
- To emphasize newer systems, their advantages, disadvantages, and evaluation methods.
- To discuss the market status of these advanced delivery systems.
Main Methods:
- Literature review of colon targeted drug delivery approaches.
- Analysis of traditional and novel drug delivery systems.
- Examination of in vitro/in vivo evaluation techniques.
Main Results:
- Newer systems like pressure-dependent, CODES technology, microsponges, pectin/galactomannan coatings, microbially triggered osmotic systems, lectins, and neoglyconjugates offer improved in vivo site specificity.
- These novel systems demonstrate better design rationale than older approaches.
- A comprehensive overview of merits, demerits, and evaluation of various systems is provided.
Conclusions:
- Continuous innovation in colon targeted drug delivery systems is essential for improved therapeutic outcomes.
- Novel systems provide enhanced site specificity and versatile release kinetics for diverse therapeutic needs.
- Further research and development are needed to optimize and commercialize these advanced delivery platforms.
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