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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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Published on: September 7, 2013

Sun protection by red wine?

Matthias Moehrle1, Helmut Dietrich, Claus Dieter Patz

  • 1Department of Dermatology, University Hospital Tuebingen. matthias.moehrle@med.unituebingen.de

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|August 5, 2008
PubMed
Summary
This summary is machine-generated.

Red wine polyphenols may offer UVB protection when consumed orally, not topically. The wine with the highest polyphenol content significantly increased the minimal erythema dose (MED), suggesting a potential role for these compounds in sun protection.

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Area of Science:

  • Dermatology
  • Nutrition Science
  • Photobiology

Background:

  • Polyphenols, plant antioxidants found in green tea and grapes, show potential in mitigating UV damage and skin cancer.
  • The UV-protective effects of wine polyphenols in humans remain largely uninvestigated.

Purpose of the Study:

  • To investigate the human UVB-protective potential of red wine polyphenols.
  • To assess both topical and systemic effects of red wine on UV-induced erythema.

Main Methods:

  • Fifteen healthy male physicians were enrolled to determine their minimal erythema dose (MED) after UVB exposure.
  • Red wine was applied topically (occluded for 20 minutes) and administered orally before UVB irradiation.

Main Results:

  • Topical application of red wine showed no significant protective effects against UVB.
  • Oral intake of red wine B resulted in a near-significant increase in MED.
  • Red wine C, with the highest polyphenol content, led to a statistically significant increase in MED (p=0.031).

Conclusions:

  • Topical wine application does not confer sun protection.
  • Oral consumption of red wine, particularly varieties rich in polyphenols, may offer systemic photoprotection.
  • Further research is warranted to elucidate the dose-dependent and duration-dependent effects of wine polyphenols on UV protection.