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Integrating biological data--the Distributed Annotation System.

Andrew M Jenkinson1, Mario Albrecht, Ewan Birney

  • 1European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, UK. andy.jenkinson@ebi.ac.uk

BMC Bioinformatics
|August 5, 2008
PubMed
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The Distributed Annotation System (DAS) protocol has been enhanced to integrate new biological data types and address bioinformatics challenges. Its expanded infrastructure and features demonstrate continued adoption in data integration.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Data Integration

Background:

  • The Distributed Annotation System (DAS) is a widely adopted protocol for dynamic integration of biological data from diverse sources.
  • DAS is continuously evolving to meet new challenges in integrative bioinformatics.

Purpose of the Study:

  • To describe the infrastructure components of the Distributed Annotation System (DAS).
  • To present an extended version of the DAS specification (Version 1.53E).
  • To detail recent developments, including support for new data types and a protein feature ontology.

Main Methods:

  • Description of existing DAS infrastructure components.
  • Development and presentation of the extended DAS specification (Version 1.53E).
  • Incorporation of new data type serving capabilities and a protein feature ontology.

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Main Results:

  • Version 1.53E of the DAS specification has been developed.
  • The extended DAS protocol now supports new biological data types.
  • An ontology for protein features has been integrated into the DAS specification.

Conclusions:

  • Extensions to the DAS protocol facilitate the integration of novel data types.
  • Improvements to DAS infrastructure address current bioinformatics challenges.
  • Increasing numbers of data sources indicate wider adoption of the DAS protocol.