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Histologic evolution of basal cell carcinoma recurrence
A Y Dixon1, S H Lee, D H McGregor
1Department of Pathology and Oncology, University of Kansas Medical Center, Kansas City.
The American Journal of Dermatopathology
|June 1, 1991
Summary
Recurrent basal cell carcinoma (BCCA) does not typically become more aggressive over time. Histologic analysis of original tumors and their recurrences indicates most BCCA are aggressive from the start.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- The behavior of recurrent basal cell carcinoma (BCCA) is debated, with conflicting theories on whether it increases in aggressiveness with each recurrence.
- Understanding BCCA's histologic evolution is crucial for determining appropriate therapeutic strategies.
Purpose of the Study:
- To investigate the histologic evolution of recurrent basal cell carcinoma (BCCA) by comparing original tumors with their recurrences.
- To determine if predictable histologic changes occur with BCCA recurrence.
Main Methods:
- Histologic comparison of 29 original basal cell carcinoma (BCCA) tumors with their subsequent recurrences.
- Analysis of various histomorphologic parameters, including fibrosis, nucleoli prominence, and mitotic frequency.
Main Results:
- Only minor, borderline statistically significant changes were observed in fibrosis, nucleoli prominence, and mitotic frequency between original tumors and recurrences.
- No significant changes were detected in other parameters previously linked to recurrence or aggressive behavior.
- The majority of recurrent BCCAs demonstrated aggressive features from their initial presentation.
Conclusions:
- Recurrent basal cell carcinoma (BCCA) is generally aggressive from the onset, rather than becoming more aggressive with subsequent occurrences.
- The histomorphology of the original basal cell carcinoma tumor can often predict its aggressive behavior and potential for recurrence.