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Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
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Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
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Long-term Depression

Long-term Depression

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Depressive Disorders: MDD and Dysthymia

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Antidepressant Drugs: MAOIs and Other Agents

Antidepressant Drugs: MAOIs and Other Agents

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Related Experiment Video

Updated: Jul 3, 2026

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

Reducing the burden of depression.

Gavin Andrews¹

¹Clinical Research Unit for Anxiety and Depression, School of Psychiatry, University of New South Wales at St Vincent's Hospital, Sydney, Australia. gavina@unsw.edu.au

Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie

|August 5, 2008

Summary

This summary is machine-generated.

The persistent burden of depression is not due to its causes, prevention, detection, or recurrence. It persists because individuals often do not seek treatment for depression, and effective care is not consistently provided.

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A New Method for Inducing a Depression-Like Behavior in Rats

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Published on: February 22, 2018

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Last Updated: Jul 3, 2026

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

A New Method for Inducing a Depression-Like Behavior in Rats

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

Area of Science:

Psychiatry
Epidemiology
Public Health

Background:

Depression represents a significant global health burden.
Understanding the reasons for its persistence is crucial for effective intervention.

Purpose of the Study:

To investigate the multifaceted reasons behind the enduring burden of depression.
To identify key factors contributing to the persistence of depression's impact.

Main Methods:

A review of the epidemiology and disability associated with depression.
Consideration of multiple potential factors for depression's persistence.

Main Results:

The study found that overwhelming causes, ineffective prevention, diagnostic challenges, and condition recurrence were not primary drivers of the persistent burden.
The primary reasons identified were related to treatment seeking and provision.

Conclusions:

The persistent burden of depression is significantly influenced by individuals not seeking treatment upon relapse.
Effective, proactive treatment is not consistently provided when individuals do seek care for depression.