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Updated: Jul 3, 2026

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

Published on: December 19, 2014

[Cryptococcosis].

Alina Osuna¹, Adelino Carragoso, Ana Lemos

¹Serviço de Medicina 2, Hospital de São Teotónio, Viseu.

Acta Medica Portuguesa

|August 5, 2008

Summary

This summary is machine-generated.

Cryptococcus neoformans infections are rare in patients with humoral immunity deficiencies. This report details two fatal cases, one in an AIDS patient and another with multiple myeloma.

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Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

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Size Matters: Measurement of Capsule Diameter in Cryptococcus neoformans

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Area of Science:

Infectious Diseases
Immunology
Mycology

Background:

Cryptococcus neoformans is an opportunistic pathogen primarily affecting individuals with compromised cell-mediated immunity.
The incidence of Cryptococcus neoformans infection has significantly increased with the human immunodeficiency virus (HIV) epidemic.
Infections in patients with humoral immunity deficiencies are rarely documented.

Observation:

This study presents two cases of Cryptococcus neoformans infection with fatal outcomes.
Case 1: A male patient with disseminated cryptococcosis, leading to an acquired immunodeficiency syndrome (AIDS) diagnosis.
Case 2: A female patient with stage III-B kappa light chain multiple myeloma presented with meningitis caused by both Cryptococcus neoformans and Listeria monocytogenes.

Findings:

The cases highlight the potential severity of Cryptococcus neoformans infections in immunocompromised individuals, even those with humoral deficiencies.
Co-infection with Listeria monocytogenes in a multiple myeloma patient underscores complex infectious challenges.
Fatal outcomes emphasize the critical need for timely diagnosis and management of cryptococcosis in at-risk populations.

Implications:

These findings suggest that humoral immunity deficiencies may not always confer protection against Cryptococcus neoformans.
The study underscores the importance of considering cryptococcosis in the differential diagnosis of meningitis in immunocompromised patients, including those with hematological malignancies.
Further research is warranted to understand the specific immunological mechanisms and clinical management strategies for cryptococcosis in patients with humoral immunodeficiencies.