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Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases
Published on: May 29, 2017
A new multi-gram synthetic route to labeling precursors for the D(2/3) PET agent 18F-fallypride
Kwangho Kim1, Nicole R Miller, Gary A Sulikowski
1Department of Chemistry and Pharmacology, Institute of Chemical Biology, Vanderbilt University, 802 Robinson Research Building, Nashville, TN 37235-1822, USA.
Bioorganic & Medicinal Chemistry Letters
|August 5, 2008
Abstract:
This Letter describes a new multi-gram synthetic protocol for the preparation of the classic tosylate labeling precursor for the D(2/3) PET agent [(18)F]fallypride. In the course of our studies, we also discovered two novel labeling precusors, the previously undescribed mesylate and chloro congeners of fallypride.
