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Related Concept Videos

Chronic Obstructive Pulmonary Disease II: Emphysema01:23

Chronic Obstructive Pulmonary Disease II: Emphysema

Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.
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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Related Experiment Video

Updated: Jul 3, 2026

Orthotopic Left Lung Transplantation in Rats
08:22

Orthotopic Left Lung Transplantation in Rats

Published on: July 3, 2025

Lung transplantation for emphysema.

G Marulli1, F Rea

  • 1Department of Cardiologic, Thoracic and Vascular Sciences, Division of Thoracic Surgery, University of Padova, Padova, Italy.

Transplantation Proceedings
|August 5, 2008
PubMed
Summary
This summary is machine-generated.

Emphysema significantly impacts global health, with many patients remaining symptomatic despite treatments. Lung transplantation offers functional improvement and better quality of life for end-stage emphysema patients, though survival benefits are unproven.

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Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP
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Last Updated: Jul 3, 2026

Orthotopic Left Lung Transplantation in Rats
08:22

Orthotopic Left Lung Transplantation in Rats

Published on: July 3, 2025

Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP
06:55

Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP

Published on: February 14, 2022

Area of Science:

  • Pulmonology and Thoracic Surgery
  • Transplantation Medicine

Background:

  • Emphysema is a leading cause of worldwide morbidity and mortality.
  • Optimal medical therapy, smoking cessation, and pulmonary rehabilitation often fail to alleviate symptoms in many emphysema patients.
  • End-stage emphysema necessitates advanced interventions, with surgical options including bullectomy, lung volume reduction, and lung transplantation.

Purpose of the Study:

  • To review the role of lung transplantation in managing end-stage emphysema.
  • To evaluate the benefits and limitations of lung transplantation for emphysema patients.

Main Methods:

  • Review of current literature on lung transplantation for emphysema.
  • Analysis of outcomes including functional status, quality of life, and survival.

Main Results:

  • Emphysema is the most frequent indication for lung transplantation.
  • Lung transplantation demonstrably improves functional capacity and quality of life in patients with end-stage emphysema.
  • A definitive survival advantage following lung transplantation for emphysema has not yet been established.

Conclusions:

  • Lung transplantation is a viable option for select end-stage emphysema patients.
  • While functional and quality-of-life improvements are evident, further research is needed to confirm survival benefits.
  • Lung transplantation remains a critical consideration in the multidisciplinary management of severe emphysema.