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Updated: Jul 3, 2026

Intralymphatic Immunotherapy and Vaccination in Mice
Published on: February 2, 2014
[Late-onset vaccination-induced subcutaneous pseudolymphoma]
Sabrina Croce1, Benoît Lhermitte, Catherine Tomasetto
1Département de pathologie, CHU de Strasbourg, hôpital de Hautepierre, 1, avenue Molière, 67098 Strasbourg cedex, France.
Abstract:
Persistent subcutaneous nodules arise on rare occasions at sites of injection of aluminium hydroxide-adsorbed vaccine. We report a case following a diphtheria, tetanus and pertussis vaccination. The late onset of the lesion, four years after the injection, led to an uncertain preoperative diagnosis. Histopathologic examination showed features of a subcutaneous pseudolymphoma. The demonstration of aluminium by Morin staining and atomic absorption spectrometry on a paraffin-embedded tissue probe supported the diagnosis of a vaccination-induced pseudolymphoma.
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