Related Experiment Video
Updated: Jul 3, 2026
16:49
Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors
Published on: July 16, 2012
[HIV and hepatitis C virus coinfection]
P Cacoub1, D Sène, E Rosenthal
1Service de Médecine Interne, AP HP, Hôpital La Pitié Salpêtrière, 83, bd de l'Hôpital, 7 5651 Paris cedex 13, France. patrice.cacoub@psl.aphp.fr
Gastroenterologie Clinique Et Biologique
|August 6, 2008
Summary
Managing chronic hepatitis C in patients with human immunodeficiency virus (HIV) is complex. Treatment success depends on viral factors, host characteristics, and early response, with significant tolerability issues noted.
Area of Science:
- Hepatology
- Infectious Diseases
- Virology
Context:
- Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) coinfection presents unique clinical challenges.
- Co-infected patients face accelerated liver disease progression and potential antiretroviral drug hepatotoxicity.
- Managing these coinfections requires careful consideration of numerous viral and host factors.
Purpose:
- To review the challenges and outcomes of treating chronic hepatitis C in HIV-coinfected patients.
- To analyze the efficacy of peginterferon alfa plus ribavirin in this population.
- To highlight predictors of treatment success and tolerability issues.
Summary:
- Treatment outcomes for chronic hepatitis C in HIV-coinfected patients receiving peginterferon alfa plus ribavirin vary, with sustained virologic response rates between 27% and 55% across five trials.
- Early virologic response is a key predictor of sustained virologic response.
- Hematologic tolerability issues are common, impacting treatment adherence and outcomes.
Impact:
- Effective management strategies are crucial for improving the long-term prognosis of HIV-HCV coinfected individuals.
- Understanding patient and viral factors is essential for optimizing treatment regimens.
- Further research is needed to enhance treatment efficacy and minimize adverse events in this vulnerable population.
Related Concept Videos
01:25Hepatitis
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
01:28Viral Hepatitis I: Introduction
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
01:27Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
01:10Retrovirus Life Cycles
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
01:26Sexually Transmitted Infections
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
02:33Retroviruses
Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...