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Related Concept Videos

Antiviral Nucleoside Inhibitors01:22

Antiviral Nucleoside Inhibitors

Antiviral Nucleoside InhibitorsAntiviral nucleoside inhibitors are structural analogs of natural nucleosides that interfere with viral DNA or RNA synthesis. These compounds selectively target viral polymerases due to their resemblance to host nucleosides, thereby disrupting viral genome replication.Mechanism of Acyclovir ActionAcyclovir is a guanosine analog with a three-carbon acyclic side chain. It selectively targets herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2),...
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Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...

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Related Experiment Video

Updated: Jul 3, 2026

Assays for the Identification of Novel Antivirals against Bluetongue Virus
12:02

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Published on: October 11, 2013

BEI Resources: supporting antiviral research.

Robert Baker1, Susan Peacock

  • 1BEI Resources, American Type Culture Collection, Manassas, VA, USA.

Antiviral Research
|August 5, 2008
PubMed
Summary
This summary is machine-generated.

The Biodefense and Emerging Infections Research Resources Repository (BEI Resources) offers quality reagents for biodefense and emerging infectious disease research. These essential materials, including priority pathogens and related products, are freely available to scientists worldwide.

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Last Updated: Jul 3, 2026

Assays for the Identification of Novel Antivirals against Bluetongue Virus
12:02

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Published on: October 11, 2013

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
09:29

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
11:34

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Published on: May 5, 2014

Area of Science:

  • Microbiology
  • Immunology
  • Virology

Background:

  • The Biodefense and Emerging Infections Research Resources Repository (BEI Resources) supports research on biodefense and emerging infectious diseases.
  • BEI Resources provides access to critical reagents for scientific advancement.

Purpose of the Study:

  • To highlight the resources available through BEI Resources.
  • To encourage investigator participation in reagent acquisition and deposition.

Main Methods:

  • BEI Resources offers a catalog of quality-assured reagents, including microorganisms (up to BSL-3) and related products like antibodies, nucleic acids, and assay kits.
  • Reagents are available free of charge to registered investigators.
  • BEI Resources also contracts for specific reagent preparation and encourages reagent deposition.

Main Results:

  • A wide array of reagents are accessible for basic research and product development in biodefense and emerging infectious diseases.
  • Many available materials are applicable to antiviral research.
  • Investigator contributions are crucial for repository growth and reagent accessibility.

Conclusions:

  • BEI Resources is a vital scientific resource providing essential, high-quality reagents for infectious disease research.
  • The repository facilitates research by offering free access to materials and supporting reagent development.
  • Investigator engagement is key to sustaining and expanding the repository's offerings.