Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Desensitization and Tachyphylaxis

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
Several...

Analgesia and Pain Management

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

Increased Intracranial Pressure ll: Pathophysiology

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...

Equilibrium and Balance

Equilibrium and Balance

The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

SafeTy and effectiveness of Atogepant accoRding to the IHS outcome categories: A multicentric, prospective observational study in real life (the 24-week STAR study).

Cephalalgia : an international journal of headache·2026

Same author

CXCL10 knockdown attenuates vestibular migraine in rats by inhibiting PI3K-mediated neuroinflammation and central sensitization.

The journal of headache and pain·2026

Same author

Oscillatory edge connectivity in pain-related regions supports machine learning identification of migraine.

The journal of headache and pain·2026

Same author

White matter microstructural alterations in episodic cluster headache outside attacks: a tract-based spatial statistics study.

The journal of headache and pain·2026

Same author

Correction: What's a migraine day? Towards a consensus definition for clinical care and research - a Delphi panel-based study.

The journal of headache and pain·2026

Same author

Myoinositol and Selenium (MYSE) Supplementation Is Associated with Favorable Changes in Thyroid Parameters and Migraine Outcomes in Patients with Migraine and Hashimoto's Thyroiditis: A Retrospective Cohort Study.

Nutrients·2026

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Habituation and migraine.

Gianluca Coppola¹, Francesco Pierelli, Jean Schoenen

¹G.B. Bietti Eye Foundation-IRCCS, Department of Neurophysiology of Vision and Neurophthalmology, Via Livenza 3, 00198 Rome, Italy. gianluca.coppola@gmail.com

Neurobiology of Learning and Memory

|August 5, 2008

Summary

This summary is machine-generated.

Migraineurs exhibit a consistent lack of neuronal habituation, reacting excessively to repetitive stimuli. This suggests underlying dysrhythmias in thalamo-cortical activity may explain migraine pathophysiology.

More Related Videos

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

An Automated Squint Method for Time-syncing Behavior and Brain Dynamics in Mouse Pain Studies

An Automated Squint Method for Time-syncing Behavior and Brain Dynamics in Mouse Pain Studies

Published on: November 1, 2024

Related Experiment Videos

Last Updated: Jul 3, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

An Automated Squint Method for Time-syncing Behavior and Brain Dynamics in Mouse Pain Studies

An Automated Squint Method for Time-syncing Behavior and Brain Dynamics in Mouse Pain Studies

Published on: November 1, 2024

Area of Science:

Neuroscience
Neurology
Migraine Pathophysiology

Background:

The most consistent brain abnormality in migraineurs between attacks is impaired neuronal information processing, specifically a lack of habituation.
Potential underlying mechanisms include increased neuronal excitability, reduced inhibition, or altered pre-activation levels, but remain uncertain.

Purpose of the Study:

To review existing data on habituation deficits in migraine patients using various methodological approaches.
To examine how habituation levels change throughout the migraine cycle.
To explore potential neurobiological explanations for observed sensory cortex hyper-responsivity.

Main Methods:

Review of studies investigating neuronal habituation in migraine patients.
Analysis of data across different methodological approaches and phases of the migraine cycle.
Examination of experimental data related to thalamo-cortical activity and monoaminergic control.

Main Results:

Consistent evidence indicates a lack of habituation in the neuronal processing of migraineurs.
Sensory cortices in migraineurs show excessive responses to repetitive stimuli, but not to brief stimulus series.
Habituation levels appear to change over the course of the migraine cycle.

Conclusions:

The findings strongly support a deficit in neuronal habituation as a key feature of the migraine brain.
A plausible explanation for the observed hyper-responsivity involves dysrhythmic thalamo-cortical activity.
Inadequate monoaminergic control is suggested as a potential cause of this dysrhythmic activity.