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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Abdominal aortic calcification in dialysis patients: results of the CORD study

Eero Honkanen1, Leena Kauppila, Björn Wikström

  • 1Division of Nephrology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland. eero.honkanen@hus.fi

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|August 5, 2008
PubMed

Insights

Abdominal aortic calcification (AAC) is common in chronic kidney disease stage 5 patients, increasing with dialysis duration and age. Lateral lumbar radiography offers a cost-effective method for assessing AAC severity and cardiovascular risk.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Radiology

Background:

  • Chronic kidney disease stage 5 (CKD5) patients exhibit high rates of vascular calcification.
  • Abdominal aortic calcification (AAC) distribution and severity are less documented than coronary calcification.
  • AAC assessment can be performed using plain radiographs.

Purpose of the Study:

  • To analyze baseline data on abdominal aortic calcification (AAC) in CKD5 patients.
  • To investigate the anatomical distribution and severity of AAC.
  • To identify predictors for AAC in this population.

Main Methods:

  • Cross-sectional study involving 47 centers across six European countries.
  • Inclusion criteria: age >or=18 years and dialysis duration >or=3 months.
  • Lateral lumbar radiography of the abdominal aorta used to determine AAC score (L1-L4 segments).

Main Results:

  • 81% of 933 patients showed calcification (AAC score >or= 1).
  • Calcification severity significantly increased from L1 to L4.
  • Independent predictors for AAC: older age, longer dialysis duration, and cardiovascular disease history.

Conclusions:

  • Lateral lumbar radiography effectively detects AAC in CKD5 patients.
  • AAC is linked to key uraemic calcification risk factors.
  • This method is accessible, cost-effective for pre-transplant workup and cardiovascular risk stratification.
Abstract

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