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Possible mechanism of the gastroprotective activity elicited by some copper(II) complexes
D Frechilla1, B Lasheras, M Ucelay
1Departamento de Farmacologia, Universidad de Navarra, Pamplona, Spain.
Abstract:
The gastroprotective activity of some copper(II) complexes has been previously described. Since mucus secretion may be a factor responsible for their gastroprotective activity, this study was designed to determine the influence of these compounds on mucous secretion in rat. The copper complexes assayed at a dose of 25 mg/kg significantly increased mucous secretion. Pre-treatment with indometacin, a cyclooxygenase inhibitor, does not influence the mucostimulant properties of these compounds. However, the effect on mucus secretion was significantly decreased by pre-treatment with a depletor of endogenous thiols, n-ethylmaleimide. These results suggest the additional role of sulfhydryl groups in the mucosal gastroprotective effect of copper(II) complexes.
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