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Updated: Jul 3, 2026

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
Left ventricular volumes and mass in marathon runners and their association with cardiovascular risk factors
Kai Nassenstein1, Frank Breuckmann, Nils Lehmann
1Department of Diagnostic and Interventional Radiology and Neuroradiology, University Duisburg-Essen, Essen, Germany.
Insights
Cardiac MRI reveals that left ventricular mass and volume in master marathon runners are influenced by age and blood pressure. Higher left ventricular muscle mass may indicate subclinical cardiac changes in older athletes.
Area of Science:
- Cardiology
- Sports Medicine
- Medical Imaging
Background:
- Assessing cardiac structure in master marathon runners is crucial for understanding exercise adaptations.
- Investigating the relationship between cardiovascular risk factors, plaque burden, and cardiac morphology in this population.
Purpose of the Study:
- To evaluate left ventricular (LV) volumes and mass using cardiac magnetic resonance imaging (MRI) in male marathon runners aged 50 years and older.
- To correlate these cardiac parameters with conventional cardiovascular risk factors and coronary atherosclerotic plaque burden.
Main Methods:
- Cardiac MRI (1.5 T) was performed on 105 healthy male marathon runners (mean age 57.3 years).
- Cine steady-state free precession images were acquired to measure LV volumes and mass.
- Cardiovascular risk factors (blood pressure, cholesterol, smoking, BMI) and coronary artery calcification (CAC) were assessed.
Main Results:
- Left ventricular muscle mass (LVMM) positively correlated with left ventricular end-diastolic volume (LVEDV), systolic, and diastolic blood pressures.
- LV end-diastolic volume increased up to age 55 and then decreased.
- Runners with higher LVMM (≥150 g) exhibited significantly greater CAC scores.
Conclusions:
- LVMM and LVEDV increases in master runners are influenced by age and blood pressure, not solely exercise.
- Left ventricular hypertrophy without volume increase may signal early subclinical cardiac alterations due to risk factor exposure.
Background:
To assess left ventricular volumes and mass by cardiac magnetic resonance imaging in relation to conventional cardiovascular risk factors and coronary atherosclerotic plaque burden in master marathon runners aged > or =50 years.
Methods:
Cardiac MRI was performed in 105 clinically healthy male marathon runners (mean age 57.3 +/- 5.7 years, range 50-71 years) on a 1.5 T MR system (Avanto, Siemens, Germany). Cine steady state free precession images in standard long and short axes views were acquired to assess left ventricular volumes and mass. Cardiovascular risk factors (blood pressure, HDL/LDL cholesterol, smoking, body mass index) were assessed and coronary artery calcification (CAC) was quantified by electron beam computed tomography.
Results:
Left ventricular muscle mass (mean LVMM = 140 +/- 27 g; 73 +/- 13 g/m(2)) increased with increasing left ventricular end-diastolic volume (mean LVEDV = 137 +/- 32 ml; 72 +/- 15 ml/m(2)) (r = 0.41, P < 0.0001) and with systolic (r = 0.33, P = 0.005) and diastolic (r = 0.28, P = 0.005) blood pressures. Left ventricular EDV increased up to the age of 55 years, but decreased thereafter. Runners with LVMM > or =150 g had significantly higher CAC scores than runners with LVMM <150 g (median CAC score 110 vs. 25, P = 0.04).
Conclusions:
Increases in LVMM and LVEDV may not only represent a response to exercise but are dependent on age and blood pressure, also. In addition, a left ventricular hypertrophy without an increase in volume may be an indicator for early subclinical cardiac alterations in response to risk factor exposure.
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