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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
An update on the relationship between the kidney, salt and hypertension
1Division of Nephrology and Hypertensiology, Department of Internal Medicine IV, Innsbruck, Austria. gert.mayer@i-med.ac.at
Abstract:
The relationship between salt intake and blood pressure has been noteworthy for a long time. Nevertheless, the complex hemodynamic alterations associated with the salt-induced blood pressure changes have become clear only quite recently. Despite this knowledge, the concept of Guyton, which postulates that any increase in blood pressure should lead to a pressure natriuresis normalising blood pressure over the long term is still valid. As a conclusion, we have to remember that an elevation of arterial pressure can only be maintained if renal function as indicated by pressure natriuresis is impaired.
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