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Electrostatic interactions between hyaluronan and proteins at pH 4: how do they modulate hyaluronidase activity

Hélène Lenormand1, Brigitte Deschrevel, Frédéric Tranchepain

  • 1Laboratoire "Polymères, Biopolymères, Membranes", UMR 6522 Université de Rouen-CNRS, 76821 Mont-Saint-Aignan Cedex, France.

Biopolymers
|August 5, 2008
PubMed
Summary

Hyaluronan (HA) and hyaluronidase (HAase) interactions are regulated by electrostatic complex formation. Protein competition for HA binding can release HAase, significantly increasing HA hydrolysis rates in biological systems.

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