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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...

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Related Experiment Video

Updated: Jul 3, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

Nutrigenomics in postgenomic era.

E V Gorduza1, L L Indrei, Valeria M Gorduza

  • 1Gr.T. Popa University of Medicine and Pharmacy Iaşi, School of Medicine, Department of Medical Genetics.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
|August 6, 2008
PubMed
Summary
This summary is machine-generated.

Nutrigenomics uses functional genomics to explore how diet and genes interact, enabling personalized nutrition. This approach aids in managing genetic disorders and complex diseases like cardiovascular disease by identifying specific genetic factors influencing dietary responses.

Related Experiment Videos

Last Updated: Jul 3, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

Area of Science:

  • Nutritional Science
  • Genomics
  • Biochemistry

Background:

  • Recent advancements in functional genomics have revolutionized our understanding of nutrition.
  • Nutrigenomics offers powerful tools to investigate the intricate links between bioactive compounds, genetic variations, and biological systems.

Purpose of the Study:

  • To explore the role of nutrigenomics in personalized nutrition and dietary recommendations.
  • To understand how nutrigenomics can improve the prevention and treatment of monogenic and multifactorial diseases.

Main Methods:

  • Utilizing functional genomics techniques.
  • Analyzing the relationships between bioactive molecules, genetic polymorphisms, and biological responses.
  • Identifying specific mutations and haplotype combinations.

Main Results:

  • Nutrigenomics facilitates personalized nutrition and dietary advice.
  • In monogenic diseases, it improves prevention and treatment by identifying mutations affecting dietary response.
  • For multifactorial diseases, it reveals susceptibility to dietary interventions and modulation of disease onset/progression.

Conclusions:

  • Nutrigenomics is key to personalized nutrition strategies.
  • It offers significant potential for managing genetic disorders and complex diseases through tailored dietary interventions.
  • Early identification of genetic factors influencing dietary response is crucial for effective disease management.