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Related Experiment Video

Updated: Feb 27, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
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Depression in the physically ill.

Raveen Hanwella1, Varuni de Silva

  • 1Department of Psychological Medicine, Faculty of Medicine, University of Colombo, Colombo. raveenhanwella@yahoo.com.uk

The Ceylon Medical Journal
|August 6, 2008
PubMed
Summary

Physically ill patients face a higher risk of depression. Selective serotonin reuptake inhibitors are common treatments, but careful prescribing is needed due to potential side effects and drug interactions.

Area of Science:

  • Medicine
  • Psychiatry
  • Pharmacology

Background:

  • Depression frequently co-occurs with various medical and surgical conditions.
  • Selective serotonin reuptake inhibitors (SSRIs) are a primary pharmacological approach for treating depression in medically compromised individuals.

Purpose of the Study:

  • To highlight the increased risk of depression in patients with comorbid medical or surgical conditions.
  • To emphasize the considerations necessary when prescribing SSRIs to physically ill patients.

Main Methods:

  • Literature review on depression in medically ill patients.
  • Analysis of treatment guidelines for SSRI use in this population.

Main Results:

  • SSRIs are generally recommended as first-line treatment for depression in the physically ill.

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  • Prescribing SSRIs requires careful consideration of potential adverse effects.

    • Conclusions:

    • While SSRIs are effective, clinicians must exercise caution when prescribing them to physically ill patients.
    • Potential side effects, hepatic and renal impairment, and drug interactions necessitate careful patient selection and monitoring.